In 1993, Ingle debuted in the role of Edward Quartermaine on General Hospital, replacing actor David Lewis in the role. In December 2003, Ingle was fired from the series and the character of Edward was set to be killed off. As the result of outrage from the series' fans, Ingle was rehired and placed on recurring status. Without a contract to keep him at GH, Ingle was free to court other offers.
Ingle left General Hospital in February 2004 in order to portray Mickey Horton on the NBC daytime soap opera Days of Our Lives, replacing the retiring John Clarke. On Days, Ingle's character became involved in a love triangle between Maggie Horton and Bonnie Lockhart.
In March 2006, Ingle left Days in order to return to General Hospital as Edward, first airing on April 18, 2006.