- Characters currently on the show are noted in bold.
- Family members through marriage are in italics. Only spouses that are currently married, or were married at the time of death appear.
- Timothy "Tim" Spencer
- Lena Eckert
- Ruby Spencer - Sister of Tim.
- Lucas "Luke" Spencer - Son of Tim and Lena; raised by Ruby.
- Barbara Jean "Bobbie" Spencer - Daughter of Tim and Lena; raised by Ruby.
- D.L. Brock
- Caroline "Carly" Benson - Daughter of Bobbie and John Durant; adopted by Frank and Virginia Benson.
- Lucas "Lucky" Spencer, Jr. - Son of Luke and Laura Webber.
- Barbara Jean "B.J." Jones - Daughter of Tony Jones and Tania Roskov; adopted by Bobbie.
- Lucas Jones - Son of Julian Jerome and Cheryl Stansbury; adopted by Tony Jones and Bobbie.
- Ethan Lovett- Son of Luke and Holly Sutton; adopted by Frank and Carol Lovett.
- Lesley Lu "Lulu" Spencer - Daughter of Luke and Laura Webber.
- Michael Corinthos III - Son of Carly and A.J. Quartermaine; adopted by Sonny Corinthos.
- Morgan Corinthos - Son of Carly and Sonny Corinthos.
- Cameron Spencer - Son of Elizabeth Webber and Zander Smith; adopted by Lucky.
- Jacob "Jake" Spencer - Son of Elizabeth Webber and Jason Morgan; legal son of Lucky.
- Josslyn Jacks - Daughter of Carly and Jasper Jacks.
- Aiden Spencer - Son of Lucky and Elizabeth Webber.
|Tim Spencer||Lena Eckert|
|Holly Sutton||Luke Spencer||Laura Webber||Tony Jones||Bobbie Spencer||John Durant|
|Lulu Spencer||Ethan Lovett||Elizabeth Webber||Lucky Spencer||B. J. Jones|
|Sonny Corinthos||Carly Benson||A. J. Quartermaine||Jasper Jacks|
|Aiden Spencer||Morgan Corinthos||Michael Corinthos|
(adopted by Sonny)